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0STAT 537 - Statistics for Molecular Genetics
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Week 1 (2007-01-08): read chapters 1 through 3 of the text
Week 2 (2007-01-15): read chapter 5 (We'll tackle it out of order: first familial risk, then identity coefficients, then continuous phenotypes, but eventually we'll get it all.)
Week 4 (2007-01-29): read chapter 6
Week 5 (2007-02-05): read chapter 7
Week 6 (2007-02-12): Mendel manual: Intro, 7 (optional), 14, 19.
Week 7 (2007-02-19): Still at chapter 7
Week 8 (2007-02-26): busy in reviewing
Week 9 (2007-03-05): Mid-term
Week 10 (2007-03-12): Spring Break
Complete Lecture Notes
: all pdf files listed below are included in this large file.
Introduction to Statistical Genetics
(including introduction to linkage
(corrected again 2007-01-24 1/3 should be 1/4 on last page)
(corrected again 2007-01-31, one of identities for covariance of continuous traits)
: Genotype elimination; allele consolidation; polygenic model; penetrance functions (sorry, some overlap with the next lecture)
: corrected for errors noticed during lecture
: corrected for errors noticed during lecture and (1) category probabilities for coupling-repulsion intercross and (2) allele frequencies for paternity testing example
lecture 8 (lab)
: map functions I
: map functions II (corrected for 3 errors detected during lecture)
: two-point with intro to linkage analysis (numbering corrected)
: multipoint linkage analysis (corrected for errors; also better explanation of 3-point locus ordering)
: troubles with parametric linkage analysis
: nonparametric linkage analysis (updated 2007-04-30: IBS probabilities and example calculation corrected)
: linkage disequilibrium analysis (updated 2007-04-30: Admixture example corrected for numerical errors)
QTL mapping lectures
: QTL mapping
- Midterm: covers material up through section 8.4.3 in lecture 12.
- example questions focusing on earlier part of course
- solutions: Short answer 8 needs to be multiplied by 2.
- Final: Thursday 12-2 in regular room
Please post your correct solutions for participation credit. Consider scanning and uploading pdfs
of your correct solutions.
: Due January 26 at 5pm (electronic is OK; delivery of written solutions can go to either office, but let me know where it is). Solution Q1_Solution_XW
: Due Feb 2 at 5pm (Saturday was a typo - now I understand why you were asking certain questions -; you can turn it in on Monday by 5) Solution
: Due Feb 12 at 5pm Solution
: Due Feb 19 at 5pm Solution Q2&3_Solution_XW
: Due Feb 26 at 5pm Solution
: Not turned in for credit; provide solutions for participation credit.Solution
: Due April 2 at 5pm Solution
: Due Monday, April 23, last week of classes (final form) Solution
: Due Mar 5 at 5pm
: Due Apr 24 at 5pm
: Due May 4 at 5pm (Take-Home